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Increased adult neurogenesis in the hippocampus of DT-treated PC/DTR mice. (A–F) The numbers of BrdU-positive (A–C, p < 0.01) and NeuroD-positive cells (D–F, p < 0.05) are greatly increased in the SGZ of DT-treated PC/DTR mice compared with controls. (G–I) Green fluorescent protein-positive cells are also markedly increased in number in the SGZ of DT-treated PC/DTR/Pomc-GFP mice (p < 0.01). CTL: control. All data are expressed as mean ± SEM. * p < 0.05, ** p < 0.01.
