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. 2013 Nov 22;69(10):1212–1226. doi: 10.1093/gerona/glt177

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© The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 3. — Obesity in aging impairs cerebrovascular autoregulatory function. (A) Steady-state changes in diameter of middle cerebral arteries (MCAs) isolated from each experimental group of mice in response to increases in intraluminal pressure. Vascular diameters are expressed as percentage of the maximally dilated passive diameter of each vessel at 80 mmHg. (B) Myogenic tone of MCAs, calculated as a percentage of the maximally dilated passive diameter of each vessel at the same intraluminal pressure. Data are mean ± SEM (n = 8 in each group). *p < .05 vs Young (standard diet [SD]); ^# p < .05 vs Young (high-fat diet [HFD]); ^$ p < .05 vs Aged (SD).