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. 2014 Sep 16;9:1563–1571. doi: 10.2147/CIA.S67263

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© 2014 Mi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Neurovascular dysfunction in the mechanism of NTG.

Notes: Neurovascular unit is a collection of different cells around blood vessels – including neurons, glia cells, and vascular cells – forming a structural and functional integrated unit to maintain the normal balance of microenvironments. Neurovascular dysfunction includes the damage of BRBs, leading to the mal-transmission between blood vessels and the microenvironment around neurons. The damaging effects include extravasation, internal transportation of circulating toxin (ET-1, Aβ), release of inflammatory cytokines or antigens, etc, which will trigger retinal gliosis and lead to neural degeneration.

Abbreviations: ET-1, endothelin-1; Aβ, amyloid-β; RGC, retinal ganglion cell; BRB, blood–retinal barrier; OBF, ocular blood flow; NTG, normal tension glaucoma.