Table 1.
Representative tumor cell genes whose expression is differentially modulated by Nanotetrac (nanopartiuclate tetrac)
| Function/gene | Up- or downregulation |
|---|---|
| Cell cycle | |
| Cyclins | ↓ |
| CDKN2C | ↑ cyclin-dependent kinase inhibitor |
| Proapoptosis | |
| CASP2 | ↑ |
| CAP8AP2 | ↑ |
| DFFA | ↑ DNA fragmentation factor subunit alpha |
| BCL2L14 | ↑ |
| Antiapoptosis | |
| XIAP | ↓ X-linked inhibitor of apoptosis protein |
| Wnt–catenin pathway | |
| CTNNA1 | ↓ |
| CTNNA2 | ↓ |
| CBY1 | ↑ nuclear inhibitor of catenin |
| Antiangiogenesis | |
| TSP1 | ↑ |
| Vascular growth factors | |
| VEGFA | ↓ |
| bFGF | ↓ |
| Growth factor receptors | |
| EGFR | ↓ |