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. 2014 Sep 22;211(10):2033–2045. doi: 10.1084/jem.20140039

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© 2014 Perreau et al.

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Figure 4. — Bacteria-specific CD4 T cells of CVID patients express high levels of PD-1. Percentages of bacteria-specific and virus-specific CD4 T cells expressing PD-1 were analyzed by flow cytometry. (A) Representative flow plots from one healthy subject (#MP) and one CVID patient (CVID-06). (B) Proportion of antigen-specific CD4 T cells expressing PD-1 in healthy subjects (n = 9) and CVID patients (n = 10). (C) Correlation between the percentage of PD-1–expressing total CD4 T cells and the percentage of PD-1–expressing bacteria-specific CD4 T cells. Statistical significance (p-values) in B were calculated using Student’s t test and in C using Spearman’s rank correlations. ***, P < 0.0001.