Table 1.
Neutralization phenotypes of primate lentiviruses.
Patient serum ID | IC50 in TZM-bl cells | Tier phenotype | |||||||
S321 | C500 | B520 | G435 | T520b | M263 | M600c | HIVIG | ||
mg/ml | |||||||||
R5 SHIVDH12-V3AD8 | 321 | 289 | 77 | 172 | 168 | 429 | 134 | 132 | 2 |
R5 SHIVAD8EO | 48 | 36 | 39 | 31 | 41 | 44 | 48 | 1,768 | 2 |
X4 SHIVDH12-CL7 | 110 | 94 | 50 | 65 | 109 | 115 | 65 | 530 | 2 |
HIV-1CAAN5342.A2 | 84 | <20 | 27 | <20 | <20 | 77 | 185 | 638 | 2 |
HIV-1MN.3 | 13,944 | 9,152 | 822 | 8,432 | 3,968 | 43,722 | 1,709 | 1.81 | 1 |
IC50 values are the serum dilution at which relative luminescence units (RLUs) were reduced 50% compared with virus control wells (no test sample).