Table 3.
NAb concentrations in tissues 24 h after passive transfer
| Tissue | A11E039 (20 mg/kg 3BNC117) | MIB (20 mg/kg 3BNC117) | ELB (control) | ||||||
| Plasma | Plasma | CSF | Plasma | Plasma | CSF | Plasma | CSF | ||
| T = 0 | T = 24 h | T = 24 h | T = 0 | T = 24 h | T = 24 h | ||||
| 1.29 µg/ml | 137.22 µg/ml | <1 µg/ml | <0.5 µg/ml | 158.53 µg/ml | <0.5 µg/ml | 1.28 µg/ml | <0.5 µg/ml | ||
| Sample 1 | Sample 2 | Sample 3 | Sample 1 | Sample 2 | Sample 3 | Sample 1 | Sample 2 | Sample 3 | |
| µg/g | µg/g | µg/g | µg/g | µg/g | µg/g | µg/g | µg/g | µg/g | |
| Cell Lysates | |||||||||
| Axillary LN | 9.26 | 8.46 | 7.53 | 5.04 | 5.27 | 5.09 | <0.5 | <0.5 | <0.5 |
| Inguinal LN | 5.91 | 13.07 | 7.19 | 6.30 | 6.35 | 5.89 | <0.5 | <0.5 | <0.5 |
| Mesenteric LN | 12.03 | 11.65 | 13.01 | 9.05 | 10.94 | 10.57 | <0.5 | <0.5 | <0.5 |
| Colonic LN | 8.92 | 10.01 | 7.11 | 6.34 | 7.03 | 6.86 | <0.5 | <0.5 | <0.5 |
| Spleen | 7.04 | 6.34 | 6.20 | 4.74 | 5.87 | 10.45 | <0.5 | <0.5 | <0.5 |
| Liver | 8.50 | 7.74 | 13.01 | 6.74 | 7.36 | 4.97 | <0.5 | <0.5 | <0.5 |
| Jejunum | 5.20 | 9.06 | 7.26 | 0.60 | <0.5 | <0.5 | <0.5 | <0.5 | <0.5 |
| Colon | 5.22 | 5.54 | 4.97 | 1.40 | 1.30 | 1.42 | <0.5 | <0.5 | <0.5 |
| Rectum | 7.39 | 4.93 | 5.42 | 1.95 | 2.39 | 2.59 | <0.5 | <0.5 | <0.5 |
| Ileum | 4.26 | 5.11 | 4.58 | 0.69 | 0.72 | 0.66 | <0.5 | <0.5 | <0.5 |
| Vagina | 1.34 | 3.67 | 2.20 | 3.29 | 4.01 | 7.40 | <0.5 | <0.5 | <0.5 |
| Cell Suspensions | |||||||||
| Axillary LN | 12.07 | 17.60 | 13.23 | 6.00 | 5.77 | 4.24 | <0.5 | <0.5 | <0.5 |
| Inguinal LN | 13.16 | 11.62 | 6.38 | 3.89 | 4.06 | 4.48 | <0.5 | <0.5 | <0.5 |
| Mesenteric LN | 12.42 | 13.45 | 12.14 | 8.06 | 8.27 | 9.14 | <0.5 | <0.5 | <0.5 |
| Colonic LN | 10.31 | 8.37 | 5.66 | 6.70 | 4.55 | 5.61 | <0.5 | <0.5 | <0.5 |
| Spleen | 6.39 | 6.42 | 4.65 | 4.69 | 5.18 | 4.76 | <0.5 | <0.5 | <0.5 |
| Liver | 10.44 | 10.69 | 13.56 | 4.84 | 4.80 | 5.39 | <0.5 | <0.5 | <0.5 |
| Jejunum | 6.17 | 3.34 | 3.86 | <0.5 | <0.5 | <0.5 | <0.5 | <0.5 | <0.5 |
| Colon | 8.81 | 9.12 | 10.50 | 2.08 | 1.53 | 1.32 | <0.5 | <0.5 | <0.5 |
| Rectum | 3.57 | 5.52 | 3.44 | 2.45 | 2.53 | 4.10 | <0.5 | <0.5 | <0.5 |
| Ileum | 2.37 | <1 | 1.33 | 0.75 | 0.93 | 0.59 | <0.5 | <0.5 | <0.5 |
| Vagina | 2.76 | 4.19 | 3.39 | 6.78 | 3.14 | 3.37 | <0.5 | <0.5 | <0.5 |
| Wick Filtrates | |||||||||
| Spleen | 14.65 | 11.40 | ND | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 |
| Liver | 57.83 | 50.04 | 57.71 | 57.47 | 38.60 | 36.35 | 1.33 | 1.20 | 0.80 |
| Jejunum | <1.5 | <1.5 | <1.5 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 |
| Colon | <1.5 | <1.5 | ND | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 |
| Rectum | 1.55 | <1.5 | <1.5 | 1.27 | <0.75 | 2.73 | <0.75 | <0.75 | <0.75 |
| Ileum | <1.5 | <1.5 | <1.5 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 | <0.75 |
| Vagina | 4.51 | 3.52 | 5.53 | 4.61 | 1.61 | <0.75 | <0.75 | <0.75 | <0.75 |
ND, not done. T, sample collection time after NAb administration