Table 1.

Shows Inhibition of Hsp90 and Hsp 70 which generates two distinct mechanisms both of which result in client protein degradation and enhanced cell survival.

Protein	Associated Neurodegenerative disease	Benefit from Hsp70 elevation in vitro?	Benefit from Hsp70 elevation in vivo?	Benefit from Hsp90 inhibition in vitro?	Benefit from Hsp90 inhibition in vivo?
Tau	Tauopathies (AD, CBD, PSP, FTDP-17)	Yes [61]	Yes [61]	Yes [62,90]	Yes [62,90]
α-synuclein	PD, DLB, MSA	Yes [220]	?	Yes[127,221]	Yes [140]
LRRK2	PD	Yes [138]	?	Yes [139]	?
SOD1	ALS	Yes [172-174]	No [176]	Yes [175]	?
TDP-43	ALS/FTD	Yes [222]	Yes [194]	Yes [223]	Yes [193]
Huntingtin	HD	Yes [211]	No [212]	Yes [83]	Yes [212]
Androgen receptor	SBMA	Yes [106,206]	Yes [210,224]	Yes[207,209]	Yes [207,208]
Ataxins	SCA	Yes [196]	Yes [197,198]	?	?