Table 3.
Variables before and after treatment of vitamin D deficiency
| Before treatment |
After treatment |
||
|---|---|---|---|
| Variable | Mean ± s.d. (n = 14) |
Mean ± s.d. (n = 14) |
P |
| Age at test (year) | 14.9 ± 1.8 | 15.6 ± 1.7 | |
| Weight (kg) | 113.5 ± 29.4 | 114.0 ± 26.4 | 0.76 |
| Height (cm) | 162.2 ± 8.0 | 163.4 ± 7.4 | 0.27 |
| BMI (kg/m2) | 43.1 ± 9.8 | 42.8 ± 9.6 | 0.51 |
| Fasting insulin (µU/ml) | 33.7 ± 13.2 | 28.1 ± 7.4a | 0.14 |
| 2-h insulin (µU/ml) | 148.9 ± 11.5 | 163.6 ± 134.3a | 0.87 |
| Fasting glucose (mg/dl) | 89.1 ± 8.3 | 84.4 ± 8.4 | 0.05d |
| 2-h glucose (mg/dl) | 105.5 ± 29.7 | 105.1 ± 30.8 | 0.96 |
| PTH (pg/ml) | 36.5 ± 17.1 | 42.2 ± 20.3a | 0.39 |
| Serum calcium (mg/dl) | 9.4 ± 0.5 | 9.3 ± 0.4 | 0.59 |
| 25(OH)D (ng/ml) | 10.6 ± 4.4 | 25.5 ± 12.1 | <0.001 |
| 25(OH)D2 (ng/ml)c | 4 ± 0 | 14.29 ± 11.46 | 0.005 |
| 25(OH)D3 (ng/ml) | 11.1 ± 4.7 | 12.0 ± 6.2 | 0.96 |
| CRP (mg/dl) | 0.8 ± 0.6 | 0.8 ± 0.5 | 0.30 |
| HOMAIR | 7.4 ± 3.3 | 5.9 ± 1.8a | 0.12 |
| WBISI (Matsuda Index) | 1.6 ± 0.6 | 1.8 ± 0.6a | 0.13 |
| Inc insulin AUC (µU/ml x120 min) |
16,962.4 ± 7,530.7 |
17,480.2 ± 8,397.9a |
0.87 |
| Inc glucose AUC (mg/dl × 20 min) |
3,726.4 ± 3,123.9 |
4,192.1 ± 2,827.1a |
0.74 |
| Hepatic IR | 1.2 × 107 ± 4.6 × 106 |
1.1 × 107 ± 4.2 × 106a |
0.21 |
| Muscle Si | 0.38 ± 0.33 | 0.30 ± 0.15b | 0.54 |
| SBP (mm Hg) | 123 ± 14 | 118 ± 15 | 0.41 |
| DBP (mm Hg) | 65 ± 9 | 64 ± 8 | 0.72 |
| Heart rate (beats/min) | 82 ± 11 | 77 ± 10 | 0.15 |
After adjusting for BMI and time (the weeks between testing) the trend for improvement remained (P = 0.05). Values indicated in boldface are statistically different.
a
n = 13,
b
n = 12.
c
For statistical analyses, a value of 4 was assigned to D2 levels reported as <4 ng/ml.
d
Exclusion of four nonresponders attenuates the P value for glucose to 0.12.