Table 5.

Effects of anatomical location of active deep brain stimulation (DBS) contact on non-motor measures.

Outcome Measure and DBS Side	N	Peak N	x	y	z	Peak t	x	y	z	Peak p	x	y	z	Peak p Region	Corrected p- value
Cognition
SDR (error in mm)
Worse	39	26	12.0	−17.5	−3.0	4.90	10.0	−16.0	−1.5	10−4	11.0	−17.5	−2.0	STN/ZI	0.060
Right (improvement)	44	29	12.5	−17.5	−3.0	−4.50	15.5	−14.5	−4.0	10−3	14.5	−15.0	−4.0	comb	0.030
Right (impairment)						3.60	10.5	−16.5	−5.5	0.01	10.5	−16.5	−5.5	STN/SN
Left	39	25	−12.5	−17.5	−3.0	3.30	−10.5	−21.5	−4.0	0.01	−11.5	−21.0	−3.0	VPL/PBP	0.405
Go/No-Go (Pr)
Worse	23	16	12.0	−17.5	−3.0	2.20	12.0	−17.0	−2.5	0.01	12.0	−17.0	−2.5	STN/ZI	0.730
Right	27	18	12.5	−17.5	−3.0	−3.50	13.0	−19.0	−7.0	0.01	13.0	−19.0	−7.0	SN	0.970
Left	22	16	−12.0	−18.5	−5.0	−4.80	−12.0	−16.5	−2.5	10−3	−12.0	−16.5	−2.5	dSTN	0.300
Psychiatric
Valence
Worse	23	18	12.2	−17.8	−3.2	4.83	14.4	−17.4	−2.0	10−4	14.0	−17.0	−3.0	dSTN	0.650
Right	24	17	12.6	−17.6	−3.2	4.00	14.0	−17.0	−3.0	10−3	13.2	−17.2	−3.2	dSTN	0.220
Left	22	13	−12.0	−18.5	−4.0	7.52	−13.0	−19.0	−4.5	10−5	−13.0	−18.5	−4.5	dSTN	0.015
Arousal
Worse	23	18	12.2	−17.8	−3.2	2.66	12.4	−20.4	−6.4	0.01	12.4	−20.4	−6.4	SN	0.870
Right	24	17	12.6	−17.6	−3.2	−3.30	14.8	−19.2	−2.0	0.01	14.4	−19.8	−2.2	ZI	0.740
Left	23	13	−12.8	−17.4	−2.8	−2.30	−11.8	−17.8	−4.2	0.01	−11.8	−17.8	−4.2	STN/SN	0.400
Anxiety
Worse	25	19	12.2	−18.2	−3.2	−5.00	14.0	−20.0	−3.0	10−4	14.2	−18.2	−2.4	dSTN	0.650
Right	26	18	12.4	−18.0	−3.2	−7.70	14.0	−19.4	−1.0	10−4	14.0	−19.4	−1.0	VPL	0.540
Left	23	14	−12.6	−18.0	−2.4	−5.88	−14.2	−19.2	−3.0	10−4	−14.2	−18.8	−3.2	dSTN	0.005
Apathy
Worse	25	19	12.2	−18.2	−3.2	4.30	14.2	−17.2	−1.8	10−3	14.2	−17.2	−1.8	STN/ZI	0.850
Right	27	19	12.2	−18.0	−3.0	2.80	11.6	−17.2	0.2	0.01	11.6	−17.2	0.2	VLA+E/ZI	0.190
Left	24	14	−12.6	−18.0	−2.4	−5.00	−11.0	−21.0	−3.0	10−3	−11.0	−20.8	−2.8	ZI	0.240
Akathisia
Worse	25	19	12.2	−18.2	−3.2	−4.00	14.0	−20.0	−2.0	10−3	13.0	−20.0	−2.0	ZI/VPL	0.110
Right	27	19	12.2	−18.0	−3.0	−5.00	14.0	−20.0	−1.0	10−3	14.2	−19.8	−2	ZI/VPL	0.190
Left	24	14	−12.6	−18.0	−2.4	−5.00	−11.0	−21.0	−3.0	10−3	−11.0	−20.8	−2.8	ZI	0.240

SDR, spatial delayed response task; mm, millimeter; Pr, ability to discriminate between ‘Go’ and ‘No-Go’ stimuli; STN, subthalamic nucleus; ZI, zona incerta; SN, substantia nigra; comb, comb system (SN fragments in white matter lateral to the STN); VPL, ventral posterior lateral thalamic nucleus; PBP, parabrachial pigmented nucleus; dSTN, dorsal STN; VLA+E, ventral lateral anterior thalamic nucleus and ventral lateral posterior thalamic nucleus – external part.