Table 5.
Outcome Measure and DBS Side |
N | Peak N |
x | y | z | Peak t |
x | y | z | Peak p |
x | y | z | Peak p Region | Corrected p- value |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cognition
| |||||||||||||||
SDR (error in mm) | |||||||||||||||
Worse | 39 | 26 | 12.0 | −17.5 | −3.0 | 4.90 | 10.0 | −16.0 | −1.5 | 10−4 | 11.0 | −17.5 | −2.0 | STN/ZI | 0.060 |
Right (improvement) |
44 | 29 | 12.5 | −17.5 | −3.0 | −4.50 | 15.5 | −14.5 | −4.0 | 10−3 | 14.5 | −15.0 | −4.0 | comb | 0.030 |
Right (impairment) | 3.60 | 10.5 | −16.5 | −5.5 | 0.01 | 10.5 | −16.5 | −5.5 | STN/SN | ||||||
Left | 39 | 25 | −12.5 | −17.5 | −3.0 | 3.30 | −10.5 | −21.5 | −4.0 | 0.01 | −11.5 | −21.0 | −3.0 | VPL/PBP | 0.405 |
Go/No-Go (Pr) | |||||||||||||||
Worse | 23 | 16 | 12.0 | −17.5 | −3.0 | 2.20 | 12.0 | −17.0 | −2.5 | 0.01 | 12.0 | −17.0 | −2.5 | STN/ZI | 0.730 |
Right | 27 | 18 | 12.5 | −17.5 | −3.0 | −3.50 | 13.0 | −19.0 | −7.0 | 0.01 | 13.0 | −19.0 | −7.0 | SN | 0.970 |
Left | 22 | 16 | −12.0 | −18.5 | −5.0 | −4.80 | −12.0 | −16.5 | −2.5 | 10−3 | −12.0 | −16.5 | −2.5 | dSTN | 0.300 |
| |||||||||||||||
Psychiatric
| |||||||||||||||
Valence | |||||||||||||||
Worse | 23 | 18 | 12.2 | −17.8 | −3.2 | 4.83 | 14.4 | −17.4 | −2.0 | 10−4 | 14.0 | −17.0 | −3.0 | dSTN | 0.650 |
Right | 24 | 17 | 12.6 | −17.6 | −3.2 | 4.00 | 14.0 | −17.0 | −3.0 | 10−3 | 13.2 | −17.2 | −3.2 | dSTN | 0.220 |
Left | 22 | 13 | −12.0 | −18.5 | −4.0 | 7.52 | −13.0 | −19.0 | −4.5 | 10−5 | −13.0 | −18.5 | −4.5 | dSTN | 0.015 |
Arousal | |||||||||||||||
Worse | 23 | 18 | 12.2 | −17.8 | −3.2 | 2.66 | 12.4 | −20.4 | −6.4 | 0.01 | 12.4 | −20.4 | −6.4 | SN | 0.870 |
Right | 24 | 17 | 12.6 | −17.6 | −3.2 | −3.30 | 14.8 | −19.2 | −2.0 | 0.01 | 14.4 | −19.8 | −2.2 | ZI | 0.740 |
Left | 23 | 13 | −12.8 | −17.4 | −2.8 | −2.30 | −11.8 | −17.8 | −4.2 | 0.01 | −11.8 | −17.8 | −4.2 | STN/SN | 0.400 |
Anxiety | |||||||||||||||
Worse | 25 | 19 | 12.2 | −18.2 | −3.2 | −5.00 | 14.0 | −20.0 | −3.0 | 10−4 | 14.2 | −18.2 | −2.4 | dSTN | 0.650 |
Right | 26 | 18 | 12.4 | −18.0 | −3.2 | −7.70 | 14.0 | −19.4 | −1.0 | 10−4 | 14.0 | −19.4 | −1.0 | VPL | 0.540 |
Left | 23 | 14 | −12.6 | −18.0 | −2.4 | −5.88 | −14.2 | −19.2 | −3.0 | 10−4 | −14.2 | −18.8 | −3.2 | dSTN | 0.005 |
Apathy | |||||||||||||||
Worse | 25 | 19 | 12.2 | −18.2 | −3.2 | 4.30 | 14.2 | −17.2 | −1.8 | 10−3 | 14.2 | −17.2 | −1.8 | STN/ZI | 0.850 |
Right | 27 | 19 | 12.2 | −18.0 | −3.0 | 2.80 | 11.6 | −17.2 | 0.2 | 0.01 | 11.6 | −17.2 | 0.2 | VLA+E/ZI | 0.190 |
Left | 24 | 14 | −12.6 | −18.0 | −2.4 | −5.00 | −11.0 | −21.0 | −3.0 | 10−3 | −11.0 | −20.8 | −2.8 | ZI | 0.240 |
Akathisia | |||||||||||||||
Worse | 25 | 19 | 12.2 | −18.2 | −3.2 | −4.00 | 14.0 | −20.0 | −2.0 | 10−3 | 13.0 | −20.0 | −2.0 | ZI/VPL | 0.110 |
Right | 27 | 19 | 12.2 | −18.0 | −3.0 | −5.00 | 14.0 | −20.0 | −1.0 | 10−3 | 14.2 | −19.8 | −2 | ZI/VPL | 0.190 |
Left | 24 | 14 | −12.6 | −18.0 | −2.4 | −5.00 | −11.0 | −21.0 | −3.0 | 10−3 | −11.0 | −20.8 | −2.8 | ZI | 0.240 |
SDR, spatial delayed response task; mm, millimeter; Pr, ability to discriminate between ‘Go’ and ‘No-Go’ stimuli; STN, subthalamic nucleus; ZI, zona incerta; SN, substantia nigra; comb, comb system (SN fragments in white matter lateral to the STN); VPL, ventral posterior lateral thalamic nucleus; PBP, parabrachial pigmented nucleus; dSTN, dorsal STN; VLA+E, ventral lateral anterior thalamic nucleus and ventral lateral posterior thalamic nucleus – external part.