Table 3.

Change in C-statistic for CVD outcomes by adding non-traditional predictors

	CVD		CHD		Stroke		HF
Predictors	CKD†	Non-CKD	CKD†	Non-CKD	CKD†	Non-CKD	CKD†	Non-CKD
Cardiac markers
cTnT	0.032 (0.009–0.054)	0.008 (0.002–0.014)	0.023 (−0.004–0.050)	0.005 (−0.001–0.011)	0.008 (−0.007–0.023)	0.006 (−0.002–0.014)	0.053 (0.020–0.085)	0.020 (0.007–0.034)
NT-proBNP	0.036 (0.016–0.056)	0.011 (0.004–0.018)	0.022 (−0.004–0.049)	0.004 (−0.001–0.009)	0.027 (0.004–0.049)	0.019 (0.0003–0.037)	0.049 (0.021–0.078)	0.029 (0.013–0.044)
Two combined	0.045 (0.020–0.069)	0.015 (0.007–0.024)	0.033 (0.003–0.063)	0.008 (0.001–0.015)	0.026 (0.004–0.049)	0.020 (0.002–0.039)	0.067 (0.032–0.103)	0.041 (0.023–0.058)
Kidney markers
Cystatin C	0.013 (−0.002–0.028)	0.005 (0.001–0.010)	0.011 (−0.006–0.027)	0.001 (−0.002–0.004)	0.000 (−0.017–0.017)	0.005 (−0.002–0.011)	0.027 (0.006–0.049)	0.015 (0.006–0.023)
B2M	0.015 (0.001–0.030)	0.010 (0.004–0.016)	0.010 (−0.005–0.024)	0.003 (−0.001–0.008)	−0.003 (−0.021–0.015)	0.010 (0.001–0.020)	0.035 (0.013–0.057)	0.019 (0.007–0.031)
BTP	0.012 (−0.001–0.026)	0.002 (−0.001–0.004)	0.008 (−0.006–0.023)	0.002 (−0.001–0.005)	0.006 (−0.012–0.023)	−0.0008 (−0.003–0.001)	0.027 (0.005–0.049)	0.001 (−0.004–0.006)
Three combined	0.015 (0.001–0.030)	0.010 (0.004–0.017)	0.011 (−0.005–0.027)	0.004 (−0.001–0.008)	0.004 (−0.012–0.020)	0.014 (0.004–0.025)	0.035 (0.013–0.056)	0.022 (0.009–0.035)
Inflammatory marker
hsCRP	0.003 (−0.007–0.014)	0.007 (0.002–0.012)	−0.001 (−0.005–0.002)	0.006 (0.002–0.011)	−0.000 (−0.010–0.010)	0.003 (−0.005–0.011)	0.018 (−0.001–0.036)	0.010 (0.000–0.019)

cTnT: cardiac troponin T, NT-proBNP: N-terminal pro–B-type natriuretic peptide, B2M: β₂ microglobulin, BTP: β-trace protein, hsCRP: high-sensitivity C-reactive protein.

^†CKD was defined as eGFRcre <60 ml/min/1.73m² or ACR ≥ 30 mg/g.

C-statistic with only conventional predictors was 0.679 and 0.697 for CVD, 0.673 and 0.721 for CHD, 0.733 and 0.712 for Stroke, 0.702 and 0.718 for HF, in CKD and in non-CKD, respectively.