Table 1.
Demographic and clinical characteristics of subjects by site (based on n=6,012 cases with clean data).
| Site | Study PI | Country | Continent | No. | Male, n (%) | Age at onset, Mean (SD) | Age at study, mean (SD) | No. deaths | Follow-up time, mean (SD) | Family history, n (%) | Diagnostic Criteria |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aasly | Norway | Europe | 379 | 238 (62.8%) | 58.5 (11.2) | 71 (9.1) | 167 | 3.3 (2.8) | 48 (12.7%) | Gelb |
| 2 | Annesi | Italy | Europe | 185 | 106 (57.3%) | 58.5 (9.9) | 66.6 (8.5) | 60 | 10.1 (2.7) | -- | Gelb |
| 3 | Bentivoglio | Italy | Europe | 99 | 45 (45.5%) | 57.5 (8) | 63.7 (8.9) | 17 | 7.7 (2.3) | 15 (15.2%) | Gelb |
| 4 | Brighina | Italy | Europe | 100 | 58 (58%) | 57.7 (9.3) | 64.9 (9.2) | 11 | 5 (2.5) | 6 (6%) | Gelb |
| 5 | Chartier-Harlin | France | Europe | 221 | 129 (58.4%) | 51 (10.3) | 62.8 (9.4) | 49 | 5.6 (1.8) | 21 (9.5%) | Gelb |
| 6 | Goldwurm | Italy | Europe | 821 | 496 (60.4%) | 56 (10.9) | 63.4 (10.7) | 78 | 3.6 (2) | 141 (17.2%) | Gibb |
| 7 | Hadjigeorgiou | Greece | Europe | 357 | 196 (54.9%) | 63.5 (9.8) | 68.3 (9.9) | 77 | 4 (2.9) | 27 (7.6%) | Bower |
| 8 | Jasinska/Krygowska | Poland | Europe | 134 | 80 (59.7%) | 51.8 (11) | 61 (10.3) | 4 | 4.3 (2.5) | 16 (11.9%) | Gibb |
| 9 | Jeon | Korea | Asia | 248 | 115 (46.4%) | 52.1 (10.2) | -- | 18 | -- | -- | Gibb |
| 10 | Kim | Korea | Asia | 98 | 41 (41.8%) | 60.2 (13.9) | 64.4 (12.8) | 6 | 3.1 (2.3) | 9 (9.2%) | Gelb |
| 11 | Krüger | Germany | Europe | 158 | 96 (60.8%) | 56.2 (11.1) | 65.4 (9.9) | 0 | 1.4 (0.3) | 43 (27.2%) | Gibb |
| 12 | Lesage | France | Europe | 287 | 177 (61.7%) | 47.5 (10.1) | 57.7 (11.4) | 1 | 1.2 (1.1) | -- | Gelb |
| 13 | Maraganore | USA | North America | 1081 | 695 (64.3%) | 61.6 (10.7) | 66.8 (10.3) | 336 | 6.8 (2.8) | 177 (16.8%) | Bower |
| 14 | Markopoulou | Greece | Europe | 59 | 28 (47.5%) | 58.6 (11.3) | 64.8 (11.4) | 7 | 1.4 (2.2) | 19 (32.2%) | Gelb |
| 15 | Mellick | Australia | Australia | 291 | 145 (49.8%) | 59.6 (10.9) | 68.3 (8.8) | 47 | 4.8 (2.8) | 32 (11.3%) | Bower |
| 16 | Morrison | United Kindom | Europe | 574 | 396 (69%) | -- | 70.1 (9) | 111 | 4.8 (2.2) | 94 (16.7%) | Gibb |
| 17 | Puschmann | Sweden | Europe | 102 | 64 (62.7%) | 62 (10.1) | 70.3 (10) | 19 | 2.7 (0.9) | 45 (44.6%) | Gibb |
| 18 | Tan | Singapore | Asia | 182 | 101 (55.5%) | 62.3 (11.5) | 66.4 (11.1) | 0 | -- | 13 (7.1%) | Gibb |
| 19 | Theuns | Belgium | Europe | 429 | 247 (57.6%) | 60.4 (11.5) | 69.7 (10.2) | 136 | 3.3 (2.4) | 74 (19.4%) | Gelb |
| 20 | Wirdefeldt | Sweden | Europe | 94 | 54 (57.4%) | 65.3 (11.2) | 72.4 (8.4) | 60 | 8.9 (3.2) | 9 (9.8%) | Gelb |
| 21 | Wszolek | USA | North America | 113 | 69 (61.1%) | 62 (11.6) | 68.7 (11.4) | 24 | 3.4 (3.5) | 52 (46%) | Gelb |
| Total | 6,012 | 3576(59.5%) | 58.2 (11.6) | 66.5 (10.6) | 1228 | 841 (14.9%) |
Jasinska/Krygowska = short hand for two investigators, Jasinska-Myga and Krygowska-Wajs; Dr. Krygowska-Wajs contributed eight cases.
Bower = Bower JH, et al.. Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976–1990. Neurology. 1999; 52(6):1214–1220.
Gelb = Gelb DJ, et al.. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999;56(1):33–39.
Gibb = Gibb WR, Lees AJ.. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988;51(6):745–752