Skip to main content
. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 3;22(3):1163–1175. doi: 10.1016/j.bmc.2013.12.027

Scheme 3.

Scheme 3

Syntheses of urea derivatives with substituted oxyoxalamide. (a) adamant-1-yl isocyanate, DMF, room temp; (b) ethyl (chlorocarbonyl)formate, Et3N, CH2Cl2, room temp; (c) 1 N NaOH, EtOH, room temp; (d) a corresponding oxyamine (in part A), EDCI, DMAP CH2Cl2, room temp; (e) CH3I, K2CO3, DMF, room temp.