Table 1.
Bcl-2 family genes and proteins on human apoptotic array microfluidic card and their detection in CLL lymphocytes.
| Gene name | Protein name | Function | Detected in array* | |
|---|---|---|---|---|
| 1 | BCL2 | Bcl-2 | Anti-apoptotic | Y |
| 2 | BCL2A1 | Bfl-1 | Anti-apoptotic | Y |
| 3 | BCL2L1 | Bcl-xL | Anti-apoptotic | Y |
| 4 | MCL1 | Mcl-1 | Anti-apoptotic | Y |
| 5 | BCL2L10 | Bcl-b | Anti-apoptotic | N |
| 6 | BCL2L2 | Bcl-w | Anti-apoptotic | Y |
| 7 | BAK1 | Bak | Pro-apoptotic Multi-Domain | Y |
| 8 | BAX | Bax | Pro-apoptotic Multi-Domain | Y |
| 9 | BOK | Bok | Pro-apoptotic Multi-Domain | N |
| 10 | BCL2L11 | Bim | Pro-apoptotic BH3-only | Y |
| 11 | BCL2L13 | Bcl-rambo | Pro-apoptotic BH3-only | N |
| 12 | BCL2L14 | Bcl-g | Pro-apoptotic BH3-only | N |
| 13 | BAD | Bad | Pro-apoptotic BH3-only | Y |
| 14 | BBC3 | Puma | Pro-apoptotic BH3-only | Y |
| 15 | HRK | Hrk | Pro-apoptotic BH3-only | N |
| 16 | PMAIP1 | Noxa | Pro-apoptotic BH3-only | Y |
| 17 | BID | Bid | Pro-apoptotic BH3-only | Y |
| 18 | BIK | Bik | Pro-apoptotic BH3-only | Y |
Bcl-2 family members analyzed through Real-time PCR using microarray fluidic card (Applied Biosystems). (* Y = Detected in all the samples analyzed (n=12), *N= Not detected in one or more samples analyzed)