Figure 4.
Alignments of protein conserved motifs/domains for three Hes-related families. (A) Hey family conserved motifs/domains. Above the basic helix-loop-helix (bHLH) and Orange domains, three conserved motifs/domains are proposed: MKRXX, DAHA, KPYRPWGXEXGAF/Y. Red lines indicate a specific glycine in the 6th position of the bHLH domain that can be considered as a molecular signature of Hey family. Brackets around dots indicate that the alignments were artificially cut for a more aesthetic representation. (B) Stich family conserved motifs/domains. Above the bHLH and Orange domains, four new conserved motifs/domains are proposed: XRDP, YHFKX, FALHX, HPISIX. (C) Dec family conserved motifs/domains. Above the bHLH and Orange domains, two new conserved motifs/domains are proposed: EDXKD and PXLYPG.