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. 2014 Sep 5;5:29. doi: 10.1186/2041-9139-5-29

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Copyright © 2014 Gazave et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Genomic clustering of the Hes superfamily genes in diverse metazoan representatives. Blue dots correspond to Hes/Hey-related genes (name mentioned above); orange squares represent non-Hes/Hey-related intervening genes; grey dots indicate non-Hes E(spl) members (name mentioned above), green lines represent microRNA. Boxes follow the same color code as in phylogenetic trees (Figures 2 and 3): cnidarians are in blue, lophotrochozoans are in purple, ecdysozoans are in orange and deuterostomians are in green. Physical linkages between Hes/Hey-related genes are found in each of these major lineages, with two to six clustered genes.