Table 3.
Effect of Treatment on Nighttime and Daytime Blood Pressure.*
| Variable | CPAP (N = 93) |
NSO (N = 95) |
HLSE (N = 97)† |
CPAP vs. HLSE | NSO vs. HLSE | CPAP vs. NSO |
|---|---|---|---|---|---|---|
| Nighttime mean arterial blood pressure | ||||||
| Baseline | 83.0±9.9 | 82.1±10.4 | 80.7±9.8 | |||
| 12 Wk | 80.9±9.3 | 83.9±12.1 | 82.9±12.9 | −3.5 (P = 0.005) | −0.0 (P = 0.97) | −3.5 (P = 0.005) |
| Nighttime mean systolic blood pressure | ||||||
| Baseline | 116.6±15.7 | 117.0±17.8 | 115.5±15.7 | |||
| 12 Wk | 114.7±14.9 | 119.3±17.8 | 117.4±19.3 | −3.3 (P = 0.11) | 0.9 (P = 0.60) | −4.2 (P = 0.02) |
| Nighttime mean diastolic blood pressure | ||||||
| Baseline | 66.2±8.4 | 64.7±8.2 | 63.4±8.5 | |||
| 12 Wk | 64.1±8.1 | 66.1±10.5 | 65.6±10.9 | −3.7 (P = 0.001) | −0.5 (P = 0.61) | −3.2 (P = 0.003) |
| Daytime mean arterial blood pressure | ||||||
| Baseline | 92.4±8.9 | 91.8±10.6 | 90.7±9.9 | |||
| 12 Wk | 90.5±8.5 | 92.8±11.3 | 91.6±11.4 | −2.1 (P = 0.09) | 0.5 (P = 0.66) | −2.6 (P = 0.04) |
| Daytime mean systolic blood pressure | ||||||
| Baseline | 128.0±13.6 | 128.7±17.1 | 127.2±14.6 | |||
| 12 Wk | 126.8±12.9 | 130.2±17.0 | 128.0±16.0 | −1.7 (P = 0.33) | 1.2 (P = 0.50) | −2.9 (P = 0.10) |
| Daytime mean diastolic blood pressure | ||||||
| Baseline | 74.6±8.2 | 72.4±9.1 | 72.4±9.2 | |||
| 12 Wk | 72.4±7.9 | 74.2±9.9 | 73.4±10.6 | −2.5 (P = 0.02) | 0.1 (P = 0.91) | −2.6 (P = 0.02) |
*
Plus–minus values are means ±SD. The between-group differences are the mean differences at 12 weeks, adjusted for study site, presence or absence of coronary artery disease, and blood pressure as measured at baseline. CPAP denotes continuous positive airway pressure, NSO nocturnal supplemental oxygen, and HLSE healthy lifestyle and sleep education.
†
For the measurement of daytime blood pressure, the number of participants in the group receiving HLSE was 99.