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Plasma pharmacokinetics of bafetinib
| Dose #1 | Dose #2 | ||||||
|---|---|---|---|---|---|---|---|
| Patient | Dose (mg) | Cmax (ng/ml) | Tmax (hr) | AUC 0-12h (ng/ml × hr) | Cmax (ng/ml) | Tmax (hr) | AUC 0-12h (ng/ml × hr) |
| 1 | 240 | 112 | 4 | 623 | 235 | 3 | 921 |
| 2 | 240 | 237 | 2 | 873 | 183 | 3 | 585 |
| 3 | 240 | 65 | 8 | 374 | 340 | 4 | 1151 |
| 4 | 240 | 285 | 4 | 1396 | 231 | 8 | 1224 |
| 5 | 240 | 32 | 12 | 169 | 330 | 8 | 2164 |
| 6 | 360 | 129 | 3 | 522 | 164 | 4 | 1000 |
| AVG = | 143 | 6 | 660 | 247 | 5 | 1174 | |
| SD = | 99 | 4 | 431 | 73 | 2 | 534 | |
