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. Author manuscript; available in PMC: 2014 Sep 23.
Published in final edited form as: Autoimmunity. 2010 Aug 9;44(2):137–148. doi: 10.3109/08916934.2010.482116

Figure 3.

Figure 3

rrLeptin protects BBDR rats from pIC+KRV induced diabetes. Female BBDR rats were treated with rrLeptin or vehicle prior to pIC+KRV treatment as described in Methods. Alzet pumps were replaced every five days for up to 29 days. A. Kaplan Meier survival curve depicts the percent of rats exhibiting diabetes free survival; n = number of rats in each group. Data are representative of two independent experiments; rrLeptin + pIC+KRV vs. vehicle + pIC+KRV (p=0.002). B. Representative pancreas sections from day 45 of a rrLeptin + pIC+KRV treated rat protected from diabetes. C. Representative pancreas sections from day 45 of a diabetic rat treated with vehicle + pIC+KRV and maintained on insulin pellets to the end of the observation period. Sections in B and C show H&E, insulin, and glucagon staining as indicated; all images are at 10x magnification.