. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Sleep Med. 2014 Jun 13;15(10):1241–1245. doi: 10.1016/j.sleep.2014.05.011

Table 3.

Odds Ratios (O.R.) from Logistic Regression Analyses for Association of Prescribed Medication Classes with RLS Diagnosis Recorded in the USRDS: ESRD Patients Initiating Dialysis 10/1/2006-12/31/2010

	USRDS patients (n=16,165) identified for case/control RLS study
Medication classes	Prescribed ever for patients with RLS Dx		Prescribed prior to RLS Dx
	O.R. (95% CI)	P-value	O.R. (95% CI)	P-value
Antidepressants	2.28 (2.10, 2.47)	<0.0001	1.20 (1.10,1.30)	<.0001
Neuroleptics	1.47 (1.30, 1.67)	<0.0001	0.84 (0.72,0.98)	0.02
Antihistamines	1.94 (1.79, 2.10)	<0.0001	0.96 (0.88,1.05)	0.37
Anti-emetics with significant dopamine blockade	1.65 (1.52, 1.80)	<0.0001	0.94 (0.85, 1.04)	0.22

CI=confidence interval, Dx=diagnosis, ESRD=end-stage renal disease, RLS=restless legs syndrome, USRDS=United States Renal Data System