Table 1.

Biodistribution data for 2-helix ⁶⁴Cu-DOTA–MUTDS with or without co-injection of large excess of unlabeled Z_HER2:477 in nude mice bearing subcutaneously xenotransplanted SKOV3 human ovarian cancer

Organ (%ID/g)	1 h	4 h	4 h block	20 h
Tumor	4.66 ± 0.38	3.34 ± 0.89*	1.76 ± 0.12	2.13 ± 1.11
Blood	1.54 ± 0.18	1.74 ± 0.54	1.34 ± 0.30	1.10 ± 0.02
Heart	1.95 ± 0.19	1.98 ± 0.26	2.05 ± 0.40	2.23 ± 0.69
Liver	27.76 ± 6.4	20.25 ± 5.77	12.27 ± 2.19	13.39 ± 3.65
Lung	4.90 ± 1.28	3.56 ± 1.04	5.49 ± 1.20	2.92 ± 0.55
Muscle	1.35 ± 0.09	0.63 ± 0.11	0.75 ± 0.12	0.62 ± 0.27
Spleen	9.12 ± 0.98	2.73 ± 0.80	2.65 ± 0.74	2.81 ± 1.30
Brain	0.34 ± 0.11	0.22 ± 0.07	0.30 ± 0.07	0.28 ± 0.14
Intestine	4.46 ± 0.82	3.60 ± 1.30	3.42 ± 1.47	2.93 ± 0.82
Skin	1.36 ± 0.28	1.06 ± 0.21	1.40 ± 0.37	1.10 ± 0.28
Stomach	3.46 ± 1.24	3.37 ± 1.31	3.00 ± 0.44	2.50 ± 1.42
Pancreas	1.41 ± 0.40	1.47 ± 0.66	0.44 ± 0.20	0.92 ± 0.04
Bone	0.99 ± 0.34	0.62 ± 0.18	0.85 ± 0.13	0.67 ± 0.13
Kidney	254.2 ± 19.10	137.69 ± 17.27	214.18 ± 48.52	24.97 ± 8.03
Uptake ratio
Tumor/Blood	3.05 ± 0.30	2.14 ± 1.05	1.36 ± 0.35	1.36 ± 0.04
Tumor/Muscle	3.48 ± 0.53	5.56 ± 2.15	2.39 ± 0.51	3.72 ± 1.65

Data are expressed as the percentage administered activity (injected dose) per gram of tissue (%ID/g) after intravenous injection of 0.69–1.01 MBq (18.7–27.4 μCi) probe at 1, 4, and 20 h p.i. (n = 3)

^*P < 0.05, compared with 4 h block