Table 2.

Biodistribution data for 2-helix ¹¹¹In-DOTA–MUTDS in nude mice bearing subcutaneously xenotransplanted SKOV3 human ovarian cancer

Organ (%ID/g)	1 h	4 h	20 h
Tumor	2.17 ± 0.51	3.41 ± 1.80	1.72 ± 0.22
Blood	1.06 ± 0.13	0.60 ± 0.06	0.18 ± 0.02
Heart	0.46 ± 0.11	0.41 ± 0.10	0.24 ± 0.08
Liver	10.24 ± 1.74	11.35 ± 1.54	8.69 ± 1.44
Lung	1.95 ± 0.67	1.21 ± 0.10	0.73 ± 0.25
Muscle	0.75 ± 0.25	0.69 ± 0.17	0.57 ± 0.15
Spleen	6.49 ± 1.17	5.10 ± 0.17	4.06 ± 0.09
Brain	0.14 ± 0.02	0.12 ± 0.01	0.10 ± 0.02
Intestine	0.36 ± 0.06	0.34 ± 0.04	0.48 ± 0.20
Skin	0.37 ± 0.14	0.38 ± 0.03	0.33 ± 0.06
Stomach	0.25 ± 0.05	0.25 ± 0.02	0.22 ± 0.05
Pancreas	0.28 ± 0.10	0.19 ± 0.02	0.20 ± 0.06
Bone	0.53 ± 0.19	0.39 ± 0.08	0.29 ± 0.05
Kidney	212.00 ± 48.23	254.67 ± 63.55	210.02 ± 31.95
Uptake ratio
Tumor/Blood	2.04 ± 0.39	5.82 ± 2.56	9.57 ± 0.93
Tumor/Muscle	3.19 ± 1.45	4.45 ± 3.16	3.18 ± 0.78

Data are expressed as the percentage administered activity (injected dose) per gram of tissue (%ID/g) after intravenous injection of 0.26–0.3 MBq (7–8 μCi) probe at 1, 4, and 20 h p.i. (n = 3)