FIG. 2.

Intrapulmonary homing and activation status of hASCs in AP-induced OA mice. Anti-inflammatory profile of infused hASCs in the murine lung. The relative mRNA expression of the gene coding for the adhesion molecule human ICAM-1, and the hASC immune modulatory genes COX-2 and TGF-β in hASC-treated murine lung tissue was determined by TaqMan RT-qPCR at days 16 and 18 after the initial AP sensitization step. Experimental groups are DMSO/SAL–hASC and AP/AP–hASC. Data are represented as fold induction of the indicated gene from the AP/AP–hASC group relative to the same gene from the DMSO/SAL–hASC group (n=3–4), ***P<0.001 compared with DMSO/SAL–hASC.