FIG. 7.

Lung histopathology in the mouse OA model. Histological evaluation of the therapeutic potential of hASC and hASC-sST2 in murine OA at 21 days after the initial AP sensitization step. Representative images of hematoxylin-and-eosin-stained, 4-μm lung sections are shown at low (upper panels) and high (lower panels) magnification. AP/AP, AP-sensitized and -challenged, untreated mice; AP/AP–hASC, AP-sensitized and -challenged, hASC-treated mice; AP/AP–hASC-sST2, AP-sensitized and -challenged, hASC-sST2-treated mice; DMSO/SAL, control noninduced, untreated mice (n=4–7 mice per group). In the left panels and denoted by arrows, AP/AP mice show a marked hyperemia, moderate leukostasis in the middle-size vessels, and hyperplasia/hypertrophy of the peribronchial musculature, when compared with the mild changes present in the AP/AP–hASC and AP/AP–hASC-sST2 mice. Scale bars=20 μm. Color images available online at www.liebertpub.com/scd