Table 1.
Top25 Most Modulated Genes in Fish Treated with the Lethal and Sub-LD Compared with Control Fish (LD/Control); (SLD/Control)
| Description (4 dpf) | FC | Reg | Description (6 dpf) | FC | Reg |
|---|---|---|---|---|---|
| LD/control comparison | |||||
| Glutaminyl-peptide cyclotransferase-like | 8.3 | Up | Tumor necrosis factor-beta | 28.2 | Up |
| Interleukin 1, beta | 5.5 | Up | Cholesterol 25-hydroxylase | 15.6 | Up |
| Alpha globin type-2, transcript variant 1 | 5.3 | Down | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | 12.9 | Up |
| Diablo, IAP-binding mitochondrial protein | 4.8 | Up | Zinc finger and BTB domain containing 25 | 9.7 | Up |
| Pyruvate dehydrogenase kinase, isoenzyme 2 | 4.1 | Up | Early growth response 2 | 9.5 | Up |
| Cyclin-dependent protein kinase 5 | 3.7 | Down | D-alanyl-D-alanine carboxypeptidase protein | 9.4 | Up |
| Patched 1 | 3.7 | Up | Pleckstrin homology domain containing, family F (with FYVE domain) member 1 | 8.6 | Up |
| Somatolactin beta | 3.3 | Up | FOS-like antigen 2 | 7.8 | Up |
| DNA fragmentation factor, alpha polypeptide | 3.3 | Up | FBJ murine osteosarcoma viral oncogene homolog B | 7.3 | Up |
| Centrosomal protein 70 | 2.9 | Up | Early growth response 3 | 7.0 | Up |
| Very large inducible GTPase 1 | 2.8 | Down | Coagulation factor IIIb | 6.8 | Up |
| Caspase b-like | 2.7 | Up | Interleukin 1, beta | 6.2 | Up |
| Polymeric immunoglobulin receptor | 2.7 | Up | Prostaglandin-endoperoxide synthase 2b | 6.0 | Up |
| Transmembrane protein 220 | 2.7 | Up | Alpha 1 type II procollagen | 5.2 | Up |
| Preimplantation protein 4-like | 2.6 | Up | Rho-related BTB domain containing 2a | 5.2 | Up |
| ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 2.4 | Up | CD276 molecule precursor | 5.1 | Up |
| Junctional adhesion molecule C precursor | 2.4 | Down | JUN B proto-oncogene | 4.9 | Up |
| Diaphanous homologue 2 | 2.4 | Up | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a | 4.4 | Up |
| Tumor necrosis factor receptor superfamily member 18 | 2.3 | Up | JUN dimerization protein 2 | 4.2 | Up |
| Interleukin 10 | 2.3 | Up | ANP32A protein | 4.1 | Up |
| Wingless-type MMTV integration site family, member 3A | 2.3 | Up | Glypican 6 | 4.1 | Up |
| Keratocan | 2.3 | Down | CCAAT/enhancer binding protein (C/EBP), beta | 4.0 | Up |
| Cytochrome P450 | 2.3 | Down | Somatolactin alpha | 4.0 | Up |
| Phosphatidylcholine-sterol acyltransferase precursor | 2.3 | Up | Prostaglandin E receptor 2b (subtype EP2) | 3.9 | Up |
| Zinc finger protein 347 | 2.3 | Up | Galactosidase, beta 1-like 2 | 3.6 | Up |
| SLD/control comparison | |||||
| Low density lipoprotein receptor | 3.4 | Up | Centrosomal protein 135 | 8.9 | Up |
| Tumor necrosis factor receptor superfamily, member 14 | 2.8 | Down | Glucose-6-phosphatase | 8.7 | Up |
| C1q-like adipose specific protein | 2.6 | Up | Zinc finger protein 37 homolog | 7.7 | Up |
| NADPH oxidase organizer 1 | 2.4 | Down | Solute carrier family 12 member 9-like | 7.3 | Up |
| Splicing factor 3a, subunit 1 | 2.4 | Up | Nipped-B homolog | 6.9 | Up |
| Macrophage expressed 1 | 2.3 | Down | Histamine receptor H2 | 6.9 | Up |
| Phosphoenolpyruvate synthase | 2.2 | Up | PRKC, apoptosis, WT1, regulator like | 5.9 | Up |
| ADP-ribosylation factor GTPase activating protein 1 | 2.2 | Up | Zinc finger protein 592 | 5.9 | Up |
| Integrin, alpha 2 | 2.1 | Up | Leucine-rich repeat-containing G protein-coupled receptor 4 | 5.7 | Up |
| Synaptosomal-associated protein 23 | 2.1 | Down | PR domain containing 1c | 5.7 | Up |
| Zinc finger protein 782 | 2.0 | Down | EF-hand calcium-binding domain-containing protein 4B | 5.3 | Up |
| Sterile alpha and TIR motif containing 1 | 5.2 | Up | |||
| Gamma-glutamyltransferase family | 5.2 | Up | |||
| Ataxin 2 | 5.2 | Up | |||
| Notum 3 | 5.1 | Up | |||
| Oxytocin receptor | 5.1 | Up | |||
| Glucagon receptor | 5.1 | Up | |||
| 40S ribosomal protein S21 | 5.1 | Up | |||
| Hyaluronan and proteoglycan link protein 1b | 5.1 | Up | |||
| Zinc finger protein 271 | 4.9 | Up | |||
| Activating molecule in beclin-1-regulated autophagy | 4.8 | Up | |||
| Glutamate receptor, ionotrophic, AMPA 3b | 4.7 | Up | |||
| Adenosine A2b receptor | 4.7 | Up | |||
| PE-PGRS family protein | 4.7 | Up | |||
| Transcription termination factor, RNA polymerase II | 4.7 | Up | |||
dpf, days postfertilization; FC, fold change; LD, lethal dose; Reg, regulation; SLD, sublethal dose.