Table 2.
Top25 Most Modulated Genes in Fish Treated With the Sublethal and Lethal Dose Compared With Control Fish (TOL/Control) and in Fish Treated With the Lethal Dose Compared to Fish Treated With the Sublethal and Lethal Dose (LD/Tol)
| Description (4 dpf) | FC | Reg |
|---|---|---|
| TOL/control comparison | ||
| Somatolactin beta | 6.6 | Up |
| Hatching enzyme 1 (he1a) | 4.0 | Down |
| FBJ murine osteosarcome viral oncogene homolog B | 3.6 | Up |
| Complement C3-H1 | 3.2 | Down |
| Splicing factor 3a, subunit 1 | 3.2 | Up |
| Transmembrane protein 144 | 3.1 | Up |
| Very large inducible GTPase 1 | 2.8 | Down |
| Transient receptor potential cation channel, subfamily V, member 6 | 2.8 | Up |
| C1q-like adipose specific protein | 2.7 | Up |
| Heat shock protein, alpha-crystallin-related, 9 | 2.5 | Up |
| Ghrelin/obestatin prepropeptide | 2.4 | Up |
| Siaz-interacting nuclear protein | 2.4 | Up |
| Cylicin-1 | 2.4 | Up |
| All-trans-13,14-dihydroretinol saturase | 2.3 | Up |
| Apolipoprotein B (including Ag(x) antigen) | 2.3 | Down |
| Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 2.3 | Down |
| Prominin-like 1 | 2.2 | Up |
| Prickle-like 1 | 2.2 | Down |
| Phosphoenolpyruvate synthase | 2.2 | Up |
| Complement factor B | 2.1 | Down |
| Prostaglandin-endoperoxide synthase 2b | 2.1 | Up |
| DnaJ (Hsp40) homolog, subfamily B, member 12 | 2.1 | Down |
| UDP glucuronosyltransferase 2 family, polypeptide A3 | 2.1 | Up |
| Peptidyl-tRNA hydrolase | 2.0 | Down |
| Zona pellucida glycoprotein 3a | 2.0 | Down |
| LD/TOL comparison | ||
| Glutaminyl-peptide cyclotransferase-like | 7.3 | Up |
| Interleukin 1, beta | 6.8 | Up |
| Trypsinogen | 5.6 | Up |
| Stanniocalcin 1 | 5.1 | Up |
| Cholesterol 25-hydroxylase | 4.6 | Up |
| S100 calcium binding protein T | 4.3 | Down |
| Histone cluster 3, H3c | 3.9 | Up |
| Wingless-type MMTV integration site family, member 2Bb | 3.8 | Up |
| Ubiquitin family | 3.7 | Up |
| Glutamate receptor-associated protein 1 | 3.7 | Up |
| Diablo, IAP-binding mitochondrial protein | 3.7 | Up |
| Transcription elongation factor B (SIII), polypeptide 3 | 3.6 | Up |
| Centrosomal protein 70 | 3.4 | Up |
| Alpha-tectorin | 3.2 | Down |
| Insulin-responsive sequence DNA-binding protein 1 | 3.1 | Down |
| Monooxygenase, DBH-like 1 | 3.1 | Up |
| Patched 1 | 3.1 | Up |
| Glutathione peroxidase 7 | 3.0 | Down |
| Phosphatidylcholine-sterol acyltransferase precursor | 2.9 | Up |
| Histone cluster 4, H4 | 2.9 | Up |
| Tumor necrosis factor receptor superfamily member 18 | 2.7 | Up |
| Membrane bound O-acyltransferase domain containing protein 1 | 2.7 | Up |
| FBJ murine osteosarcome viral oncogene homolog B | 2.7 | Down |
| Epidermal growth factor receptor | 2.6 | Up |
| Leucine zipper and W2 domains 1b | 2.6 | Up |
TOL, tolerized.