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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: Neuroscience. 2014 Aug 20;278:154–164. doi: 10.1016/j.neuroscience.2014.08.008

Fig. 2.

Fig. 2

Effects of the D1 receptor antagonist SCH23390 on reconsolidation of cocaine self-administration in wild-type mice. Wild-type mice were subjected to 3 h daily self-administration training and showed stable IVSA. Mice then went through 3 h extinction training daily. Extinction data were from the last day of training. Once the extinction criterion was met, mice were subjected to a 10-min retrieval. Reconsolidation was tested 24 h, 48 h or 1 week after the retrieval (A), or 24 h after no retrieval manipulations (B). SCH23390 was administered i.p. immediately after the retrieval or during no retrieval manipulations. N = 6–8 mice for each group. Data represent mean ± SEM. *P<0.05, **P<0.01, and ***P<0.001 SCH23390 versus saline treatment. Recon: reconsolidation. SCH-0.08: SCH23390-0.08 mg/kg. SCH-0.22: SCH23390-0.22 mg/kg.