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. 2014 Jul 18;13(5):958–961. doi: 10.1111/acel.12243

Figure 2.

Figure 2

Humanin expression is regulated by the GH/IGF-I axis in humans. (A–C) Plasma humanin levels were measured from GH-deficient children (age 11.7 ± 1.8) before and after a 30-day GH treatment (N = 11/group). Pretreatment humanin levels were (A) not correlated with GH (r = −0.04, P = 0.9) but (B) highly negatively correlated with IGF-I (r = −0.69, P < 0.05). (C) Plasma humanin levels in these children were measured before and after GH treatment. (D) Plasma humanin levels of an Ecuadorian cohort with GH receptor deficiency (Laron Syndrome) and matched controls (N = 6/group). (E) Model of GH/IGF-I axis regulation of humanin and its effect on longevity. Data shown as mean ± SEM. Student’s t-test, *P < 0.05.