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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: Neuroscience. 2014 Aug 17;278:70–80. doi: 10.1016/j.neuroscience.2014.08.009

Figure 6.

Figure 6

Effect of binding site mutations in GluK2 or GluK5 on the activation of homomeric and heteromeric receptors by kainate.

A. Representative current traces in response to 5 sec applications of kainate from receptors containing wild-type or mutated subunits as indicated.

B. Concentration-response relationships for kainate were constructed by measuring the peak current amplitude and normalizing this to the maximal peak response to a saturating concentration of kainate for each cell. Symbols represent mean ± SEM (n=4–5 cells) and solid (wild-type) or dashed (mutated) lines show the fit of a four-parameter logistic equation to the averaged data.