Table 1.
Patient and Disease Characteristics
| AllN=401 | Post-XRT Neck Dissection N=80 (20%) | Post-XRT Neck Dissection Positivea N=21 (26%) | ||
|---|---|---|---|---|
| Patient characteristics | ||||
| Sex | Male | 352 (88%) | 72 (90%) | 20 (28%) |
| Age at diagnosis, y | Mean (range) | 57.9 (36–84) | 57.1 (38–84) | 60 (44–84) |
| Smoker | Current | 76 (19%) | 15 (20%) | 4 (27%) |
| Former | 128 (32%) | 25 (31%) | 6 (24%) | |
| Never | 197 (49%) | 40 (49%) | 11 (28%) | |
| Disease characteristics | ||||
| Primary site | Tonsil | 202 (50%) | 35 (44%) | 9 (26%) |
| Base of tongue | 192 (48%) | 43 (53%) | 11 (25%) | |
| Other | 7 (2%) | 2 (3%) | 1 (50%) | |
| T classification | 1 | 121 (30%) | 29 (36%) | 8 (28%) |
| 2 | 159 (40%) | 33 (41%) | 7 (21%) | |
| 3 | 68 (17%) | 10 (13%) | 3 (30%) | |
| 4 | 53 (13%) | 8 (10%) | 3 (30%) | |
| N classification | 1 | 41 (11%) | 4 (5%) | 0 (0%) |
| 2a | 28 (7%) | 11 (10%) | 4 (36%) | |
| 2b | 218 (54%) | 43 (54%) | 10 (23%) | |
| 2c | 87 (21%) | 14 (17%) | 5 (36%) | |
| 3 | 27 (7%) | 8 (10%) | 2 (25%) | |
| Size of largest lymph node, cm | ≥3 | 134 (33%) | 33 (42%) | 9 (27%) |
| Lowest neck level involved | 2 | 214 (53%) | 44 (55%) | 8 (18%) |
| 3 | 140 (35%) | 25 (31%) | 7 (28%) | |
| 4 | 47 (12%) | 11 (14%) | 6 (55%) | |
| Treatment | ||||
| Chemotherapy | None | 47 (12%) | 12 (15%) | 2 (17%) |
| CC | 130 (32%) | 23 (28%) | 6 (26%) | |
| IC | 87 (22%) | 18 (22%) | 3 (17%) | |
| IC+CC | 137 (34%) | 27 (36%) | 10 (37%) | |
| Concurrent drugs | None | 134 (33%) | 30 (38%) | 5 (17%) |
| Cisplatin | 99 (25%) | 13 (16%) | 4 (31%) | |
| Carboplatin | 54 (14%) | 12 (15%) | 2 (17%) | |
| Cetuximab | 93 (23%) | 20 (25%) | 9 (45%) | |
| Other | 22 (5%) | 5 (6%) | 1 (20%) | |
Abbreviations: CC, concurrent chemoradiation; IC, induction chemotherapy; XRT, radiotherapya Percentage is of patients who underwent post-XRT neck dissection