Table 2. ITC derived binding and thermodynamic profiles for the interaction of harmalol to various polynucleotides^a.

Polynucleotides	K b (×106 M−1)	n	ΔGo (kcal/mol)	ΔHo (kcal/mol)	TΔSo (kcal/mol)
poly(dA-dT).poly(dA-dT)	0.44±0.02	0.18	−7.74	−2.00	5.74
poly(dA).poly(dT)	0.30±0.02	0.11	−7.51	+0.30	7.81
poly(dG-dC).poly(dG-dC)	3.86±0.07	0.30	−9.04	−5.00	4.04
poly(dG).poly(dC)	0.22±0.03	0.12	−7.33	−1.98	5.35

^aAverage of three determinations in CP buffer of 15 mM [Na⁺], pH 6.8. Values of ΔG^o were determined using the equation ΔG^o = −RT ln K _b and TΔS^o = ΔH^o−ΔG^o. n denotes the binding site size.