Table 2.
Implantation Rate | Clinical Pregnancy Rate | Live Birth Rate | |
---|---|---|---|
Quartile (range, μg/day) | |||
Adjusted Mean (95% CI) | |||
| |||
Total Folate (in DFE) | |||
Q1 ((<1262) | 0.46 (0.35, 0.57) | 0.39 (0.29, 0.51) | 0.30 (0.21, 0.42) |
Q2 (1262–1778) | 0.62 (0.50, 0.72) | 0.56 (0.44, 0.67)* | 0.47 (0.35, 0.59)* |
Q3 ((1779–2352) | 0.64 (0.51, 0.74)* | 0.58 (0.46, 0.70)* | 0.42 (0.30, 0.55) |
Q4 (>2352) | 0.68 (0.57, 0.78)* | 0.63 (0.52, 0.74)* | 0.56 (0.43, 0.67)* |
P trend | 0.01 | 0.007 | 0.01 |
Supplemental Folate | |||
Q1 ((<400) | 0.43 (0.31, 0.55) | 0.41 (0.29, 0.53) | 0.35 (0.24, 0.48) |
Q2 (400–543) | 0.66 (0.55, 0.75)* | 0.55 (0.44, 0.65) | 0.43 (0.32, 0.54) |
Q3 (544–800) | 0.58 (0.46, 0.70) | 0.55 (0.42, 0.66) | 0.39 (0.28, 0.52) |
Q4 ((>800) | 0.67 (0.56, 0.77)* | 0.62 (0.51, 0.73)* | 0.55 (0.43, 0.66)* |
P trend | 0.03 | 0.03 | 0.07 |
Food Folate | |||
Q1 (<371) | 0.58 (0.47, 0.69) | 0.47 (0.36, 0.58) | 0.35 (0.25, 0.47) |
Q2 (372–436) | 0.55 (0.44, 0.66) | 0.51 (0.40, 0.63) | 0.41 (0.30, 0.52) |
Q3 (437–534) | 0.61 (0.49, 0.71) | 0.56 (0.45, 0.67) | 0.49 (0.37, 0.60) |
Q4 (>534) | 0.64 (0.52, 0.75) | 0.60 (0.48, 0.71) | 0.49 (0.37, 0.61) |
P trend | 0.35 | 0.10 | 0.08 |
All analyses were run using generalized linear mixed models with random intercepts, binomial distribution, and logit link function.
Indicates a p-value < 0.05 comparing that quartile vs. first quartile.
Data are predicted marginal means adjusted for total calorie intake, age, BMI, race, smoking status, infertility diagnosis, and protocol type, unless otherwise specified.