Table 2.

Associations between folate intake and clinical outcomes in 232 women (353 initiated cycles) from the Environment and Reproductive Health Study.

	Implantation Rate	Clinical Pregnancy Rate	Live Birth Rate
Quartile (range, μg/day)
	Adjusted Mean (95% CI)
Total Folate (in DFE)
Q1 ((<1262)	0.46 (0.35, 0.57)	0.39 (0.29, 0.51)	0.30 (0.21, 0.42)
Q2 (1262–1778)	0.62 (0.50, 0.72)	0.56 (0.44, 0.67)*	0.47 (0.35, 0.59)*
Q3 ((1779–2352)	0.64 (0.51, 0.74)*	0.58 (0.46, 0.70)*	0.42 (0.30, 0.55)
Q4 (>2352)	0.68 (0.57, 0.78)*	0.63 (0.52, 0.74)*	0.56 (0.43, 0.67)*
P trend	0.01	0.007	0.01
Supplemental Folate
Q1 ((<400)	0.43 (0.31, 0.55)	0.41 (0.29, 0.53)	0.35 (0.24, 0.48)
Q2 (400–543)	0.66 (0.55, 0.75)*	0.55 (0.44, 0.65)	0.43 (0.32, 0.54)
Q3 (544–800)	0.58 (0.46, 0.70)	0.55 (0.42, 0.66)	0.39 (0.28, 0.52)
Q4 ((>800)	0.67 (0.56, 0.77)*	0.62 (0.51, 0.73)*	0.55 (0.43, 0.66)*
P trend	0.03	0.03	0.07
Food Folate
Q1 (<371)	0.58 (0.47, 0.69)	0.47 (0.36, 0.58)	0.35 (0.25, 0.47)
Q2 (372–436)	0.55 (0.44, 0.66)	0.51 (0.40, 0.63)	0.41 (0.30, 0.52)
Q3 (437–534)	0.61 (0.49, 0.71)	0.56 (0.45, 0.67)	0.49 (0.37, 0.60)
Q4 (>534)	0.64 (0.52, 0.75)	0.60 (0.48, 0.71)	0.49 (0.37, 0.61)
P trend	0.35	0.10	0.08

All analyses were run using generalized linear mixed models with random intercepts, binomial distribution, and logit link function.

^*Indicates a p-value < 0.05 comparing that quartile vs. first quartile.

Data are predicted marginal means adjusted for total calorie intake, age, BMI, race, smoking status, infertility diagnosis, and protocol type, unless otherwise specified.