Table 3.

Influence of +1245 MT1A A/G SNP on clinical and biochemical parameters

	G− genotype Baseline	G+ genotype Baseline	p value
CRP (mg/dL)	0.55 ± 1.46	0.42 ± 0.58	0.91
Albumin (g/dL)	4.1 ± 0.2	4.0 ± 0.2	0.41
Glycemia (mg/dL)	96.7 ± 13.8	96.1 ± 9.1	0.53
Total cholesterol (mg/dL)	223.2 ± 41.8	219.2 ± 34.3	0.70
HDL-cholesterol (mg/dL)	53.1 ± 14.2	49.2 ± 16.2	0.28
Triglycerides (mg/dL)	122.1 ± 52.8	133.7 ± 72.5	0.24
AGEs (ng/mL)	1.31 ± 0.50	1.66 ± 0.62	0.036
ROS (MFI)	4.1 ± 2.1	24.0 ± 18.3	0.01
pSOD (U/mL)	21.53 ± 2.85	21.18 ± 3.26	0.65
GPx (nmol NADPH/min/mL)	0.100 ± 0.006	0.099 ± 0.006	0.37
CAT (μmol/min/mg prot)	20.80 ± 2.67	21.40 ± 2.92	0.35
Zn plasma levels (μM)	10.58 ± 2.21	11.12 ± 2.24	0.22
Zn granulocytes (nmol/mg protein)	0.21 ± 0.12	0.20 ± 0.12	0.92
MT (MFI)	87.52 ± 32.13	89.21 ± 38.78	0.88
iZnL	1.27 ± 0.12	1.24 ± 0.09	0.44
iZnR	0.18 ± 0.07	0.17 ± 0.06	0.47

Data are mean ± SD

Comparisons between G+ (AG+GG) and G− (AA) genotype were performed by ANCOVA analysis correcting for age, gender and country

Bold values indicate a significant difference