Table 4.

Genes related to GAG metabolism and extracellular matrix dynamics differentially expressed between Mobilee™ and placebo groups post-intervention (p < 0.05), but not pre-intervention

Gene	Name	Systematic name	Function	Fold change Mobilee™ vs. placebo	p value
GUSB	Glucuronidase-beta	NM_000181	Hydrolase that degradates GAG	−1.22	0.027
HS6ST1	Heparan sulfate 6-O-sulfotransferase 1	NM_004807	Enzyme responsible for 6-O-sulfation of heparan sulfate	−1.22	0.009
MMP23B	Matrix metallopeptidase 23B	NM_006983	Protease involved in the breakdown of the extracellular matrix	−1.30	0.028
XYLT2	Xylosyltransferase II	NM_022167	Enzyme that initiates the biosynthesis of GAGs including chondroitin sulfate, heparan sulfate, heparin, and dermantan sulfate in proteoglycans	−1.32	0.004