Table 1.
Year | Graft type | Number of patients | Median age | ANC > 500/μL (median, d) | aGVHD II-IV(%) | Extensive cGVHD (%) | 100 d TRM (%) | Relapse rate (%) | Survival (%) |
2004[5] | UCB | 150 | 16-60 | 27 | 41 | 51 | 63 | 17 (3 yr) | 26 (3 yr) |
MUD BM | 367 | 16-60 | 20 | 48 | 35 | 46 | 23 | 35 | |
MMUD BM | 83 | 16-60 | 18 | 51 | 40 | 65 | 14 | 20 | |
2004[6] | UCB | 98 | 25 | 26 | 26 | 30 | 44 | 23 (2 yr) | 36 (2 yr) |
MUD BM | 584 | 32 | 19 | 39 | 46 | 38 | 13 | 42 | |
2007[19] | UCB | 100 | 38 | 22 | 60 | 23 | 8 | 17 (3 yr) | NA |
MRD (BM and PB) | 71 | 40 | 17 | 55 | 30 | 4 | 26 | ||
2008[10] | UCB | 148 | 29 | NA | NA | NA | 41 | 26 (2 yr) | 35 (2 yr) |
MUD PB | 518 | 35 | NA | NA | NA | 27 | 30 | 45 | |
MMUD PB | 210 | NA | NA | NA | NA | 42 | 24 | 36 | |
MUD BM | 243 | 29 | NA | NA | NA | 26 | 28 | 48 | |
MMUD BM | 111 | NA | NA | NA | NA | 37 | 26 | 38 | |
2009[62] | UCB AML | 173 | 38 | NA | 32 | 8 | 32 (2 yr) | 31 (2 yr) | 43 (2 yr) |
MUD BM | 311 | 38 | NA | 35 | 20 | 22 | 24 | 60 | |
UCB ALL | 114 | 34 | NA | 28 | 10 | 24 | 31 | 49 | |
MUD BM | 222 | 32 | NA | 42 | 17 | 25 | 24 | 57 | |
2010[15] | MRD | 204 | 40 | NA | 65 | 47 | 24 (5 yr) | 43 (5 yr) | NA |
MUD | 152 | 31 | NA | 80 | 43 | 14 | 37 | NA | |
MMUD | 52 | 31 | NA | 85 | 48 | 27 | 35 | NA | |
DUCB | 128 | 25 | NA | 60 | 28 | 34 | 15 | NA |
ANC: Absolute neutrophil count; aGVHD: Acute graft versus host disease; cGVHD: Chronic graft versus host disease; TRM: Treatment related mortality; UCB: Umbilical cord blood; MUD: Matched unrelated donor; BM: Bone marrow; MMUD: Mismatched unrelated donor; NA: Not available; MRD: Matched related donor; PB: Peripheral blood stem cells; AML: Acute myeloid leukemia; ALL: Acute lymphoblastic leukemia; DUCB: Double umbilical cord blood.