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. 2014 Sep 26;6(4):371–379. doi: 10.4252/wjsc.v6.i4.371

Table 1.

Hematopoietic cell transplantation after myeloablative conditioning in adult patients comparing umbilical cord blood and other donor sources

Year Graft type Number of patients Median age ANC > 500/μL (median, d) aGVHD II-IV(%) Extensive cGVHD (%) 100 d TRM (%) Relapse rate (%) Survival (%)
2004[5] UCB 150 16-60 27 41 51 63 17 (3 yr) 26 (3 yr)
MUD BM 367 16-60 20 48 35 46 23 35
MMUD BM 83 16-60 18 51 40 65 14 20
2004[6] UCB 98 25 26 26 30 44 23 (2 yr) 36 (2 yr)
MUD BM 584 32 19 39 46 38 13 42
2007[19] UCB 100 38 22 60 23 8 17 (3 yr) NA
MRD (BM and PB) 71 40 17 55 30 4 26
2008[10] UCB 148 29 NA NA NA 41 26 (2 yr) 35 (2 yr)
MUD PB 518 35 NA NA NA 27 30 45
MMUD PB 210 NA NA NA NA 42 24 36
MUD BM 243 29 NA NA NA 26 28 48
MMUD BM 111 NA NA NA NA 37 26 38
2009[62] UCB AML 173 38 NA 32 8 32 (2 yr) 31 (2 yr) 43 (2 yr)
MUD BM 311 38 NA 35 20 22 24 60
UCB ALL 114 34 NA 28 10 24 31 49
MUD BM 222 32 NA 42 17 25 24 57
2010[15] MRD 204 40 NA 65 47 24 (5 yr) 43 (5 yr) NA
MUD 152 31 NA 80 43 14 37 NA
MMUD 52 31 NA 85 48 27 35 NA
DUCB 128 25 NA 60 28 34 15 NA

ANC: Absolute neutrophil count; aGVHD: Acute graft versus host disease; cGVHD: Chronic graft versus host disease; TRM: Treatment related mortality; UCB: Umbilical cord blood; MUD: Matched unrelated donor; BM: Bone marrow; MMUD: Mismatched unrelated donor; NA: Not available; MRD: Matched related donor; PB: Peripheral blood stem cells; AML: Acute myeloid leukemia; ALL: Acute lymphoblastic leukemia; DUCB: Double umbilical cord blood.