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This illustration shows combination therapies aiming to achieve maximal and synergistic anti-leukemia stem cells effect. HDACi: Histone deacetylase inhibitor; HMTi: Histone methyltransferase inhibitor; BETi: Bromodomain and Extra-Terminal inhibitor; Brd4: Bromodomain-containing protein 4; Ac: acetylation; Me: methylation; NK-cell: Natural killer-cell.
