Table 2. rCSP/Ad35CS Heterologous Prime-Boost Regimens.
Group | Injection Type and Day (D) | Regimen Abbreviation | ||
D = 0 | D = 14 | D = 36 | ||
1 | Ad35CS | Ad35CS | Ad35CS | Ad35CS 3x |
2 | GLA-SE+rCSP | GLA-SE+rCSP | GLA-SE+rCSP | GLA-SE 3x |
3 | GLA-SE+rCSP | Ad35CS | Ad35CS | GLA-SE 1x/Ad35CS 2x |
4 | GLA-SE+rCSP | GLA-SE+rCSP | Ad35CS | GLA-SE 2x/Ad35CS 1x |
5 | Ad35CS | GLA-SE+rCSP | GLA-SE+rCSP | Ad35CS 1x/GLA-SE 2x |
6 | Ad35CS | Ad35CS | GLA-SE+rCSP | Ad35CS 2x/GLA-SE 1x |
7 | Naïve |
C57BL/6 mice were immunized with rCSP formulated in GLA-SE or Ad35CS according to the regimens shown.