Table 2.
Diagnostic criteria of HRS
| Major criteria |
| 1 Chronic or acute liver disease with advanced liver failure and portal hypertension |
| 2 Low GFR, as indicated by a serum creatinine of > 1.5 mg/dL or a 24-h creatinine clearance < 40 mL/min |
| 3 Exclusion of shock, ongoing bacterial infection, volume depletion, and the use of nephrotoxic drugs |
| 4 No improvement in renal function despite stopping diuretics and volume repletion with 1.5 L of saline |
| 5 No proteinuria or ultrasonographic evidence of obstructive uropathy or parenchymal renal disease |
| Minor criteria1 |
| 1 Urine volume lower than 500 mg/day |
| 2. Urine sodium lower than 10 mEq/L |
| 3 Urine osmolality > plasma osmolality |
| 4 Urine blood cells < 50 per high-power field |
| 5 Serum sodium concentration lower than 130 mEq/L |
1
Only major criteria are necessary for the diagnosis of hepatorenal syndrome.