Figure 6.

Cajal-Retzius cells contact CA1 pyramidal cells via AMPA and NMDA glutamate receptors. A, Anatomical reconstruction of a CA1 pyramidal cell in which a postsynaptic response with a d-AP5-sensitive component was recorded following light stimulation [gray, stratum lacunosum-moleculare (l-m)]. B, Top, Postsynaptic responses recorded at V_h = −60 mV in control conditions and after the addition of NBQX (20 μm). Three sweeps are superimposed for each condition. Bottom, Summary plot (empty circles, mean; bars, SE) of the time course of the effect of NBQX application (black bar) on the postsynaptic responses (norm peak, normalized peak). C, Top, Postsynaptic responses (three sweeps superimposed) recorded at V_h = −30 mV before and after the application of d-AP5 (50 μm). Averaged traces in the two conditions (black trace, control; gray trace, d-AP5) are superimposed after scaling. Bottom, Summary graphs of the effect of d-AP5 on the normalized amplitude (left, norm peak, empty circles are individual experiments) and the half-width (right, empty squares are individual experiments) of the postsynaptic responses.