Table 1.
Hemodynamics
| Baseline | Pre-occlusion | Ischemia | Reperfusion | |
|---|---|---|---|---|
| 30 min | 2 h | |||
| Heart rate, beats · min−1 | ||||
| WT Control | 430 ± 26 | 426 ± 26 | 383 ± 39*# | 363 ± 26*# |
| WT Ex-4 | 432 ± 16 | 413 ± 41 | 402 ± 16 | 398 ± 9 |
| Cav-3 KO Control | 413 ± 27 | 415 ± 25 | 383 ± 25 | 381 ± 32 |
| Cav-3 KO Ex-4 | 416 ± 28 | 419 ± 26 | 376 ± 39 | 357 ± 36*# |
| Mean arterial pressure, mmHg | ||||
| WT Control | 75 ± 6 | 75 ± 6 | 70 ± 6 | 65 ± 10*# |
| WT Ex-4 | 78 ± 5 | 75 ± 5 | 72 ± 7 70 ± 8 | |
| Cav-3 KO Control | 77 ± 4 | 75 ± 4 | 71 ± 3* 65 ± 6*# | |
| Cav-3 KO Ex-4 | 76 ± 5 | 75 ± 5 | 70 ± 3 | 66 ± 5*# |
| Rate-Pressure Product, beats · min−1 · mmHg · 103 | ||||
| WT Control | 32.0 ± 3.3 | 32.0 ± 1.4 | 26.7 ± 3.5*# | 23.7 ± 4.7*# |
| WT Ex-4 | 33.6 ± 2.7 | 31.2 ± 4.1 | 29.2 ± 3.5 | 28.0 ± 3.6* |
| Cav-3 KO Control | 31.9 ± 2.2 | 31.1 ± 2.6 | 27.0 ± 2.3*# | 25.0 ± 3.5*# |
| Cav-3 KO Ex-4 | 31.5 ± 3.7 | 31.5 ± 3.2 | 26.4 ± 3.5*# | 23.4 ± 2.6*# |
Data are mean ± SD. Wild-type (WT) or caveolins-3 knockout (Cav-3 KO) mice were randomly exposed to exendin-4 (Ex-4).
*Significantly (P < 0.05) different from baseline (intragroup comparison).
#Significantly (P < 0.05) different from pre-occlusion (intragroup comparison).