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. 2014 Sep 10;12:56. doi: 10.1186/s12964-014-0056-8

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© Börlin et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Impact of minor changes to autophagosome movements in long-term simulations of optimized integrative model. A-C Schematic describing bi-directional movement of autophagosomes (AP) between the cell periphery (P) and nucleus (N). Arrows denote probabilities for AP agent movements. D-E 100 Simulations corresponding to 14 days (20160 min) were performed, using indicated altered transport probabilities. Steady-state vesicle dynamics at 14 days are reported. D Mean vesicle count with standard deviation. E Mean vesicle size with standard deviation. Numbers on the y-axis represent the probability of autophagosome movement towards the nucleus, centered on the standard value of 85% (indicated by the blue shaded box).