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. 2014 Sep 10;12:56. doi: 10.1186/s12964-014-0056-8

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© Börlin et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overview of the integrative model of autophagy. Schematic describing interactions of the four agent types from Figure 1, expanded by the addition of nutrients. Each agent is color-coded; phagophores (PP) in grey, autophagosomes (AP) in red, lysosomes (LYS) in yellow and autolysosomes (AL) in purple. Two distinct nutrient-type global values are included: bound nutrients (blue) and free nutrients (green). Merging arrows represent fusion events between the two agents to form or expand an autolysosome. Black arrows represent degradation events. Arrows marked with BAF or ND indicates that this pathway is influenced under conditions with BAF or by ND. Black arrows represent degradation events.