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. 2014 Sep 11;18(5):527. doi: 10.1186/s13054-014-0527-8

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© Slimani et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Endotoxemia results in greater cardiac depression and worse myocardial injury in old mice. Adult and old mice were treated with lipopolysaccharide (LPS, 0.5 mg/kg, iv) or normal saline. Left ventricular pressure-volume loops and plasma levels cardiac troponin-I (cTn-I) were analyzed 6 h after treatment. Old mice displayed greater reduction in left ventricular performance (A) and higher levels of cTn-I in plasma (B). Data are expressed as mean ± standard error; *P <0.05 versus corresponding control (Ctrl); ^# P <0.05 versus adult mice with LPS treatment.