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. 2014 Sep 17;11:155. doi: 10.1186/s12974-014-0155-x

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© Dinel et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Postnatal day 14 (PND14) neonatal lipopolysaccharide (LPS) decreases the phosphorylated glucocorticoid receptor/glucocorticoid receptor ratio in the prefrontal cortex at adulthood. Representative immunoblots corresponding to the phosphorylated form of glucocorticoid receptor (PGR) and total glucocorticoid receptor (GR) in the prefrontal cortex (A) and the hippocampus (B) of adult mice receiving either NaCl or LPS at PND14 are presented. Immunoblots were quantified and the ratios for PGR/GR (left graph panels) or GR/actin were calculated (right graph panels). Data are expressed as mean ± SEM (n = 10/group). *P <0.05, for NaCl compared to LPS. Plasma corticosterone levels were measured by radioimmunoassay (RIA) in the plasma (C). Data are expressed as mean ± SEM (n = 10/group). *P <0.05, for NaCl compared to LPS.