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. 2014 Sep 17;11:155. doi: 10.1186/s12974-014-0155-x

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© Dinel et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A lipopolysaccharide (LPS) challenge at adulthood impairs spatial memory in postnatal day 14 (PND14) neonatal LPS mice. Spatial memory performance was evaluated in the Y-maze test by measuring the time spent exploring the novel and the familiar arms. Measures were performed 24 h after intraperitoneal (i.p.) administration of saline or lipopolysaccharide (LPS, 100 μg/kg) in adult mice. They were assessed over a 5-min test and after a 30-min retention intertrial interval (ITI). Data are expressed as means ± SEM (n = 15/group). *P <0.05, **P <0.01, for familiar arm compared to novel arm.