Table 2.
Effect of E. singularis organic extract and its semi-purified fractions (F-EtOH, F-Ac, F-MeOH/CH 2 Cl 2 ), and of reference drugs (ranitidine and omeprazol) on gastric ulcer induced by HCl/ethanol in rats
| Treatment | Dose (mg/kg) | Ulcer index (mm) | Inhibition (%) |
|---|---|---|---|
| Vehicle | - | 78.5±3,49 | - |
| Organic extract | 50 | 31.52±2,42** | 59.84 |
| 100 | 24.46±2,48** | 68.84 | |
| 200 | 19.49±3,48** | 75.16 | |
| F-EtOH | 5 | 43.36±1,52* | 44.76 |
| 10 | 37.20±3,05** | 52.61 | |
| 25 | 23.33±1** | 70.27 | |
| F-Ac | 25 | 61.97±0,7 | 21.05 |
| F-MeOH/CH2Cl2 | 5 | 66.59±2,33 | 15.17 |
| 10 | 58.78±2,82 | 25.11 | |
| 25 | 29.17±4,04** | 62.84 | |
| Ranitidine | 60 | 27.47±2.3** | 65 |
| Omeprazol | 30 | 9.78±0,81* | 87.53 |
Values are expressed as mean±SEM; n=6 animals. *P<0.01, **P<0.001.