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Correlation between TTF-1 immunohistochemistry and presence of EGFR activating mutation
| Series | EGFR mut + (N) | EGFR mut- (N) | |
|---|---|---|---|
| Vincenten et al. [20] | NPV | ||
| TTF-1 + | 105 | 403 | 96% |
| TTF-1 - | 9 | 228 | |
| Leary et al. [12] | NPV | ||
| TTF-1 + | 15 | 40 | 100% |
| TTF-1 - | 0 | 15 | |
| This series | NPV | ||
| TTF-1 + | 29 | 140 | 98% |
| TTF-1 - | 1 | 43 | |
| Pooled results | NPV | ||
| TTF- 1 + | 149 | 583 | 97% |
| TTF-1 - | 10 | 286 |
EGFR mut+: presence of activating EGFR mutation; N: number; TTF-1: thyroid transcription factor 1; NPV: negative predictive value.
