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. Author manuscript; available in PMC: 2014 Sep 24.
Published in final edited form as: Curr Mol Med. 2012 Dec;12(10):1282–1296. doi: 10.2174/156652412803833517

Fig. 1. Protective mechanisms of hypothermia in HIBI and TBI.

Fig. 1

The neuroprotection of hypothermia in HIBI and TBI is mediated by various mechanisms including the inhibition (⊥) of oxidative stress, apoptosis, inflammation, and excitotoxicity, as well as the enhancement (→) of cerebral energy metabolism. In addition hypothermia reduces BBB disruption in TBI (⊥).